FIGURE

Fig. 5

ID

ZDB-FIG-220811-18

Publication

Truong et al., 2022 - Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

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Fig. 5

The vertical axis represents 19 broad chemotype-categories obtained by collapsing Toxprint chemotype into 36 super chemotypes. The horizontal axis represents the number of compounds carrying that chemotype. Each rectangular section represents bioactivity in the indicated assay (Morphology, EPR and LPR). Teal fill represents the compounds that carried a certain chemotype and induced bioactivity in a specific, whereas grey indicates compounds that did not induce bioactivity but carried that chemotype. Chemotypes that were statistically enriched (Fisher Exact Test p-value <0.05) among bioactives or non-bioactives are shown in darker shades. The vertical red dotted line indicates the total number of compounds that induced bioactivity within each assay.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Journal of hazardous materials, 431, Truong, L., Rericha, Y., Thunga, P., Marvel, S., Wallis, D., Simonich, M.T., Field, J.A., Cao, D., Reif, D.M., Tanguay, R.L., Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish, 128615, Copyright (2022) with permission from Elsevier. Full text @ J. Hazard. Mater.