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Fig. 1

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ZDB-FIG-220811-14

Publication

Truong et al., 2022 - Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

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Fig. 1

Overall Experimental Design.

Embryonic zebrafish were developmentally exposed from 6 to 120 hpf (top; hpf = hours post-fertilization). The embryos were exposed to 10 concentrations of PFAS (plate design: all shades of blue), 4 concentrations of PC (parathion ethyl positive control; gray), and vehicle control (white). At 24 and 120 hpf, embryos were assessed for mortality and 10 morphological endpoints and a summary endpoint (ANY). Examples are: CRAN = craniofacial malformations, EDEM = edema, AXIS = bent axis. Embryonic and Larval Photomotor Response are behavior assays in which movement was assessed in response to 2 flashes of light or alternating light/dark cycles at 24 and 120 hpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Journal of hazardous materials, 431, Truong, L., Rericha, Y., Thunga, P., Marvel, S., Wallis, D., Simonich, M.T., Field, J.A., Cao, D., Reif, D.M., Tanguay, R.L., Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish, 128615, Copyright (2022) with permission from Elsevier. Full text @ J. Hazard. Mater.