FIGURE

Fig. 5

ID

ZDB-FIG-220808-67

Publication

Zeitler et al., 2022 - High calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat

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Fig. 5

Figure 5.High-calorie and high-calorie, high-fat diets led to ectopic lipid deposition and displacement of organelles. Transmission electron microscopy of proximal tubules from fish fed the normal-calorie diets (normal diet and high-fat diets) showed evenly spaced cells with elongated mitochondria distributed throughout the cell and few endocytic vesicles. In contrast, proximal tubule cells in the high-calorie diets (high-calorie and high-calorie, high-fat diets) had bulging apical membranes and cytoplasm filled with lipid droplets, displacing the nucleus and mitochondria to the basal portion of the cell. Scale bars = 5 µm. HC, high-calorie diet; HCHF, high-calorie, high-fat diet; HF, high-fat diet; ND, normal diet.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	high fat, increased food availability increased food availability
Observed In:	proximal straight tubule lipid droplet renal tubule lipid droplet
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Renal Physiol.