FIGURE
Fig. 1
- ID
- ZDB-FIG-220804-19
- Publication
- Delnoy et al., 2022 - Novel mRNA therapy restores GALT protein and enzyme activity in a zebrafish model of classical galactosemia
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 1
Study design. Naked, LNP1 and LNP2-packaged hGALT mRNAs provided by Moderna Inc. were injected in CG zebrafish (galt KO) zebrafish at one-cell stage (0–1 h post fertilization, hpf) and intravenous (48–56 hpf). GALT activity, protein expression (merely one-cell stage injections) and Gal-1-P and galactonate (merely intravenous injections) were assessed at 5 days post fertilization (dpf). LNP, lipid nanoparticle; mRNA, messenger RNA; hpf, hours post fertilization; dpf, days post fertilization; LNP1, LNP1-packaged mRNA; LNP2, LNP2-packaged mRNA; Naked, naked mRNA; Gal-1-P, galactose-1-phosphate. Figure is created with BioRender.com
|
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ J. Inherit. Metab. Dis.