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Fig. 1
Study design. Naked, LNP1 and LNP2-packaged hGALT mRNAs provided by Moderna Inc. were injected in CG zebrafish (galt KO) zebrafish at one-cell stage (0–1 h post fertilization, hpf) and intravenous (48–56 hpf). GALT activity, protein expression (merely one-cell stage injections) and Gal-1-P and galactonate (merely intravenous injections) were assessed at 5 days post fertilization (dpf). LNP, lipid nanoparticle; mRNA, messenger RNA; hpf, hours post fertilization; dpf, days post fertilization; LNP1, LNP1-packaged mRNA; LNP2, LNP2-packaged mRNA; Naked, naked mRNA; Gal-1-P, galactose-1-phosphate. Figure is created with BioRender.com
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Full text @ J. Inherit. Metab. Dis.