FIGURE

Fig. 7

ID

ZDB-FIG-220725-61

Publication

Holm et al., 2022 - The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

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Fig. 7

Genetic associations between sleep duration and the human MIR137 locus. Chromosome location of MIR137 with surrounding SNPs and genes. The plot depicts the location of MIR137 (dark-green box) on chromosome 1 (98453556 to 98515419 GRCh37/hg19). Genes in close genomic proximity (±1,000,000 base pairs) are marked with dark-blue boxes. The −log₁₀-transformed values of P values for SNPs of 19 sleep phenotypes from the UK Biobank are plotted on the x axis. All genome-wide-significant SNPs with values of P ≤ 5E-8 are marked in dark red and annotated, whereas SNPs from the sleep duration GWAS with a P value between 5E-8 and 0.05 are indicated in light red. All other SNPs for different GWAS phenotypes are marked in gray. The size of the points increases with the significance of the SNP association.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA