FIGURE

Fig. 6

ID

ZDB-FIG-220722-8

Publication

Rusnati et al., 2021 - Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin

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Fig. 6

Effect of UniPR1331 on VEGF/VEGFR2-dependent EC proangiogenic activation.

a HUVECs stimulated with VEGF and increasing concentrations of UniPR1331 were counted using the MACSQuant Analyzer. Data are expressed as proliferation fold increase in respect to HUVECs cells left untreated (dashed line). b HUVEC monolayers were wounded and incubated with VEGF and UniPR1331. Then, the extension of the repaired wound area was evaluated. Data are expressed as percent or repaired area in respect to the extension of the original wound. c Microphotographs of wounded HUVEC monolayers taken after 24 h of incubation with or without VEGF and UniPR1331. Dashed lines mark the edge of the wound at t₀. d HUVEC spheroids embedded in fibrin gel were incubated with VEGF and UniPR1331. Then, radially growing cell sprouts were counted. e Microphotographs of spheroids incubated with VEGF and UniPR1331. Data shown in a, b, and d are the mean ± S.E.M. of three independent experiments (*P < 0.05 and **P < 0.01).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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