FIGURE

Fig. 5

ID

ZDB-FIG-220718-5

Publication

Li et al., 2022 - The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m⁶A recognition

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Figure 5. Conserved role of zebrafish ythdc2 in male fertility (A) Generation of ythdc2 knockout (?46) zebrafish. Heterozygous crosses give rise to animals in the expected Mendelian ratios. (B) Crosses of heterozygous and homozygous ythdc2?46/?46 knockout males or females with wildtype partners. Crosses with homozygous knockout males do not produce any embryos, indicating that they are infertile. See also Figure S5B. (C) Hematoxylin and Eosin staining of adult zebrafish testes showing that the infertile homozygous ythdc2?46/?46 fish lack sperm. Scale bar in ?m is indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ythdc2^ug801/ug801 ythdc2^ug801/+
Observed In:	female organism male organism male organism seminiferous tubule seminiferous tubule sperm spermatid development whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cell