FIGURE

Fig. 4

ID

ZDB-FIG-220705-35

Publication

Chen et al., 2022 - Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model

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Fig. 4

Dose–response curves for A549 cells treated with [2](PF6)2 24 h after seeding, and irradiated with green light (520 nm, 15 min, 21 mW cm−2, 19 J cm−2) 24 h after treatment (green data points) or left in the dark (black data points). (a) A549 cells were cultured in 2D cell monolayers. SRB end-point assay was carried out at 48 h after irradiation (light) or 72 h after compound addition (dark). (b) A549 cells were cultured as 3D multicellular tumour spheroids in ultra-low attachment flask. The spheroids were treated with [2](PF6)2 at day 4, irradiated at day 5 (520 nm, 15 min, 21 mW cm−2, 19 J cm−2), and their viability assayed at day 7 by a CellTiter-Glo 3D cell viability assay. Results are presented as means ± SD from three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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