FIGURE

Fig. 5

ID

ZDB-FIG-220628-5

Publication

Imani et al., 2022 - Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility

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Fig. 5

Modulation of enhanced migratory capacity of HPS lung fibroblasts (HPSLF) by losartan in vivo. HPSLF and normal lung fibroblasts (NLF) were treated with losartan or vehicle (PBS) and labeled with a CM-Dil live-cell marker (red). 75 cells were injected into the yolk sac of 48 h post-fertilization Tg(fli1:GFP, green) zebrafish embryos expressing GFP in their blood vessels. HPSLFs exhibit stronger migratory capacity than NLFs at 24 h (not shown) and 48 h after injection. Arrows indicate the migration of labeled fibroblasts from the yolk sac into outlined regions of zebrafish embryos. Treatment with losartan reduces HPSLF migratory capacity compared to baseline

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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