FIGURE

Fig. 4

ID

ZDB-FIG-220628-32

Publication

Lin et al., 2022 - The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

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Fig. 4

Inhibition of pseudovirus entry. (A) The intracellular luciferase activity (implying the rate of pseudovirus entry in RLU) was detected at different concentrations/dilutions of wild-type pseudovirus. (B) The entry of wild-type pseudovirus was disrupted by PCRR_water and PCRR_EtOH in dose-dependent manners. (C) These extracts also inhibited the entry of the omicron variant into the host cells. The inhibition rate was calculated based on the luciferase activity, which was normalized to the luciferase activity without any treatment. A SARS-CoV-2 neutralizing antibody at a concentration of 1 µg/mL was employed as a positive control. The data represent mean ± SD; n = 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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