FIGURE

Fig. 4

ID

ZDB-FIG-220620-36

Publication

Wang et al., 2020 - RNA-based therapies in animal models of Leber congenital amaurosis causing blindness

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Fig. 4

Ataluren and Amlexanox treatment in Rd3 and Rd12 mice assessed at P120. (A) H&E sections of wildtype (Wt) retina compared to Rd3 retina when treated with either Ataluren (AT) or AT plus Amlexanox (AM). ONL, outer nuclear layer; INL, inner nuclear layer. Size bar = 50 μm. (B) H&E sections of Wt retina compared to Rd12 retina when treated with combined AT plus AM postnatally (P4-P120) and prenatally and continued postnatally (E12-P120). RPE, retinal pigment epithelium; OS, outer segments; IS, inner segments. Size bar = 50 μm. (C) Cryosections with TUNEL-staining (red) in Wt and Rd12 retina treated with combined AT plus AM either postnally from P4-P120 or from E12-P120. Sections were counterstained with DAPI. Size bar in all panels = 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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