FIGURE

Fig. 2

ID

ZDB-FIG-220620-34

Publication

Wang et al., 2020 - RNA-based therapies in animal models of Leber congenital amaurosis causing blindness

Other Figures

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Fig. 2

cep290 morphology (Mt) compared to wildtype (Wt) embryos. (A) Lateral and dorsal views of wholemount morphology in embryos at 24 hpf. Telencephalon (arrows) is projected forward in cep290 embryos. F, forebrain ventricle; M, midbrain ventricle. (B) Wildtype brain development at 48 hpf, 72 hpf, and 6 dpf. Left panels, wholemount morphology; right panels, transverse H and E sections through the midbrain. sb, swim bladder; mb, midbrain; onl, outer nuclear layer of the retina; inl, inner nuclear layer. Size bar = 100 μm. (C) cep290 brain development at 48 hpf, 72 hpf, and 6 dpf. Left panels, wholemount morphology; right panels, transverse H and E sections through the midbrain. h, hydrocephalus; nbl, neuroblastic layer; *periocular edema. Size bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cep290^{sa1383/sa1383}
Observed In:	brain development eye forebrain ventricle hindbrain midbrain pericardium retina layer formation swim bladder tectal ventricle telencephalon
Stage Range:	Prim-5 to Day 6

Phenotype Detail

Acknowledgments

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