FIGURE

Figure 1

ID

ZDB-FIG-220616-12

Publication

Niu et al., 2022 - Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish

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Figure 1

nlrc3-like deficiency promotes host control of the mycobacterial proliferation during early infection. (A) Zebrafish embryo infections and bacterial fluorescence intensity. The red arrow indicates the duct of Cuvier, the site where bacteria were injected. (B) Representative images for M. marinum:Wasabi infected embryos at 3 dpi. (C) Statistics of relative green fluorescence intensity at the indicated time points taken from two independent biological replicates. (D) Process for calculating granuloma-like structure in zebrafish embryos: i original image; ii. the image after fluorescence-pixelation processing – the area of the red pixels represents the relative size of each granuloma; iii. Calculation of the area of the red pixels. (E) Graph showing the number of large, small and all granuloma-like structures in nlrc3-like -/- and control embryos. (B, D) Scale bar = 200 μm *p ≤ 0.05; **p ≤ 0.01; ns, not statistically significant (p>0.05)..

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol