FIGURE

Fig. 6

ID
ZDB-FIG-220603-57
Publication
Xu et al., 2022 - Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development
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Fig. 6

Figure 6. Attenuated postnatal cardiac lymphangiogenesis in developing and growth-restricted Gprc5b−/− mice. (A) Whole-mount immunostaining of podoplanin (PDPN)-positive cardiac lymphatics of P7 Gprc5b+/+ hearts (left) and Gprc5b−/− hearts (right). (B) Quantification of PDPN-positive vessel area of dorsal or ventral surface of the heart. (C) Quantification of total PDPN-positive vessel length of dorsal or ventral surface of the heart. Significance calculated using unpaired t-test. (D) Whole-mount immunostaining of podoplanin-positive cardiac lymphatics of P21 Gprc5b+/+ hearts (left), non-growth-restricted (middle) and growth-restricted (right) Gprc5b−/− hearts. High magnification of insets provided to the right of full heart images. Blue border = Gprc5b+/+, red border = Gprc5b−/−. Scale bar = 2 mm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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