FIGURE

FIGURE 3

ID

ZDB-FIG-220424-3

Publication

Ouyang et al., 2022 - An EGFP Knock-in Zebrafish Experimental Model Used in Evaluation of the Amantadine Drug Safety During Early Cardiogenesis

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FIGURE 3

CPAAHTs exposure induced ectopic expression of vmhc gene in the atrium and caused cardiac-looping defects to dose-dependently. (A,B) Representative images of heart-looping morphology (A) and quantification analysis (B) of the percentage of the vmhc^KI–EGFP KI embryos with corresponding cardiac-looping structure after exposure to different concentrations of CPAAHTs compared to untreated control at 48 hpf. The arrow points to the ectopic expression of the EGFP signal in the atrium. The dotted line outlines the shape of the atrium. V, ventricle. A, atrium. N = 129–315, chi-squared test.

Expression Data

Gene:	EGFP
Fish:	myh7^hn2Tg/hn2Tg
Condition:	chemical treatment by environment: amantadine
Anatomical Terms:	atrium cardiac ventricle
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myh7^hn2Tg/hn2Tg
Condition:	chemical treatment by environment: amantadine
Observed In:	atrium cardiac ventricle regulation of heart looping
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cardiovasc Med