FIGURE
Figure 1
- ID
- ZDB-FIG-220416-78
- Publication
- Kasica et al., 2022 - The Inhibitory Effect of Selected D2 Dopaminergic Receptor Agonists on VEGF-Dependent Neovascularization in Zebrafish Larvae: Potential New Therapy in Ophthalmic Diseases
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Figure 1
Figure 1. A set of microphotographs and a graph documenting inhibition of 5 mM CoCl2-derived increased angiogenesis of hyaloid-retinal vessels (HRVs) (asterisk) resulting from co-treatment with dopaminergic agonists in 3 dpf Tg(Fli-1:EGFP) zebrafish larvae. (a) The control untreated larva; HRVs are marked with *. (b) 5 mM CoCl2 exposure resulted in increased HRVs branching. (c–g) Co-treatment with 2.5 µM/L bromocriptine, 2.5 µM/L cabergoline, 2.5 µM/L pergolide and 2.5 µM/L bevacizumab, respectively, resulted in significant inhibition of HRVs abnormal branching. (g) The graph presenting the kappa coefficient (ĸ) values (ratio of HRVs area to eyeball area) in investigated groups. (one-way ANOVA, GraphPad Prism 5, *** p < 0.001).
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