FIGURE

Figure 5

ID

ZDB-FIG-220416-66

Publication

El Fersioui et al., 2022 - Premature Vertebral Mineralization in hmx1-Mutant Zebrafish

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Figure 5

DMH1-mediated inhibition of BMP signaling reduces the progression of vertebral mineralization: Wildtype and hmx1^mut10 embryos were treated with 50 μM DMH1 at 2 dpf and placed in E3 medium at 3 dpf. Alizarin red staining to detect mineralized structures was performed at 7 and 8 dpf (left, lateral view, right ventral view). Wildtype and hmx1^mut10 control embryos treated with DMSO (A). Precocious vertebral mineralization was inhibited in DMH1-treated hmx1^mut10 embryos at 7 dpf (B). At 8 dpf, treated hmx1^mut10 embryos still presented a vertebral mineralization pattern similar to wildtype embryos (B). Bar, (A,B) 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT hmx1^iro2/iro2
Condition:	chemical treatment by environment: DMH1
Observed In:	cranial skeletal system development vertebra bone mineralization
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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