FIGURE

Fig 4

ID

ZDB-FIG-220415-22

Publication

Madelaine et al., 2020 - Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation

Other Figures

All Figure Page

Back to All Figure Page

Fig 4

MCH-dependent melanosome contraction relies on Mchr2 activity.

(A-D) Dorsal melanocytes of control (A), mchr2 homozygous mutant (B), mchr2 homozygous mutant; Tg(hs:mch1) (C) or mchr2 homozygous mutant; Tg(hs:mch2) (D) black adapted larvae at 7 dpf following heat-shock. (E) Melanosome coverage was quantified in control, mchr2 homozygous mutant, mchr2 homozygous mutant; Tg(hs:mch1) or mchr2 homozygous mutant; Tg(hs:mch2) larvae at 7 dpf. Dorsal view with anterior up. Error bars represent s.d. *P<0.05, **P<0.001, ***P<0.0005, determined by t-test, two-tailed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT mchr2b^{zf3415/zf3415} mchr2b^{zf3415/zf3415}; zf3412Tg mchr2b^{zf3415/zf3415}; zf3580Tg
Condition:	heat shock
Observed In:	integument background adaptation melanocyte cellular pigment accumulation melanocyte melanosome melanocyte melanosome localization
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.