FIGURE

Figure 1

ID

ZDB-FIG-220402-44

Publication

Chen et al., 2022 - Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Mutant schema of atm and infertility phenotype. (A) Cas9-based engineering system of the atm introduced a stop code before functional domain. (B) Relative expression level of atm mRNA at different location (shown in (A)) of atm+/− and atm−/− zebrafish compared to WT (n = 3). (C) General observation of wild-type and atm−/− zebrafish at 6 months old. (D) Gender ratio of atm−/− compared with WT zebrafish (Over 50 fish each group were calculate). (E) HE stains of testis. SG, spermatogonia; SC, spermatocyte; ST, spermatid; SZ, spermatozoa. (F) Ratio of each stage of meiosis in atm−/− zebrafish testis compared to WT (n = 3). The statistical significance was analyzed using the two-tailed Student’s t-test. Data are shown as means ± SEM.

Expression Data

Gene:	atm
Fish:	TU atm^{zf3863/zf3863} (TU) atm^zf3863/+ (TU)
Anatomical Term:	caudal fin
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atm^{zf3863/zf3863} (TU) atm^zf3863/+ (TU)
Observed In:	caudal fin female organism sperm spermatid spermatocyte spermatogonium testis spermatogenesis (all 7)
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomedicines