FIGURE
Figure 3
- ID
- ZDB-FIG-220329-17
- Publication
- Alkowari et al., 2022 - Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients
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Figure 3
Figure 3. Cellular analysis of novel MYO6 variant. (A) Western blot of whole-cell lysates and membrane proteins from HeLa cells transfected with plasmids carrying human MYO6WT and MYO6p.E60Q. (B) Quantification ratio of the normalized integrated density of MYO6 expression from membrane/whole proteins. (C) Representative immunofluorescence staining images of HeLa cells labeled by MYO6 (red), pan-cadherin (green), and DAPI (blue). (D) Quantification of the relative fluorescence intensity of MYO6. (E) Quantification of the ratio of the normalized relative fluorescence intensity of MYO6/pan-cadherin. All values are represented as the mean ± SEM from independent experiments. Statistically significant differences were assessed by (B) unpaired t-test, * p < 0.05 or (D,E) one-way ANOVA followed by Tukey’s multiple comparisons, * p < 0.05; *** p = 0.0001; **** p < 0.0001.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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