FIGURE

Fig. 1

ID

ZDB-FIG-220215-18

Publication

Tanaka et al., 2021 - Oxidative stress inducers potentiate 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated pre-cardiac edema in larval zebrafish

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Fig. 1

Paraquat augments 2,3,7,8-tetrachlorodibenzo-p-dioxin-evoked pre-cardiac edema in an antioxidant-sensitive manner. Eleutheroembryos were treated with 0.1 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (0.1 TCDD or TCDD) or a vehicle (0.1% DMSO) (Control) beginning at 24 hpf. Paraquat (Para) (an oxidative stress inducer) (100 µg/ml), 20 µM N-acetylcysteine (NAC) (A), and 10 mM ascorbic acid (Asco) (B) were also included in some cases. Chemicals were newly changed at 48 hpf. At 55 hpf, the area of the pre-cardiac cavity was determined as an index of TCDD-induced edema (pre-cardiac edema, dashed circles in insets). Results are expressed as percentage of the control (means ± SEM, n=19–21). Values with different letters are significantly different (P<0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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