FIGURE

Figure 1.

ID
ZDB-FIG-220214-33
Publication
Minnoye et al., 2020 - Cross-species analysis of enhancer logic using deep learning
Other Figures
All Figure Page
Back to All Figure Page
Figure 1.

Comparative epigenomics reveals conservation of two main melanoma states. (A) Evolutionary relationship between the six studied species, represented by a phylogenetic tree (NCBI taxonomy tree). ATAC-seq profiles of the 26 melanoma cell lines are shown for three regulatory regions. (B) ATAC-seq profiles of the human melanoma lines for the SOX10 locus. Lines are colored by the melanocytic (MEL, in blue) or mesenchymal-like (MES, in orange) melanoma state. (C) Total number of ATAC-seq regions observed across all samples of a species are colored based on whether they are not alignable, alignable, or conserved accessible in human. (D) PCA clustering based on the accessibility of the 29,619 alignable regions across all six species. (E) ATAC-seq profiles of MEL and MES lines of different species for an intronic MLANA enhancer and the upstream region of MMP3.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genome Res.