FIGURE
Figure 4.
- ID
- ZDB-FIG-220210-6
- Publication
- Yao et al., 2022 - Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors
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Figure 4.
Compound 29e bind to the colchicine site of tubulin and inhibit the microtubule polymerisation. (A) 2 D model of the interaction between compound 29e and the amino acid residues of tubulin colchicine site. (B) 3 D model of the binding position of compound 29e. (C) RMSD tendency of two systems (29e, colchicine) versus time in the 60 ns MD simulation. (D) Effect of compound 29e on tubulin binding of [3H] colchicine. (E) Compound 29e affected microtubule assembly in vitro. (F) The effects of 29e on the organisation of cellular microtubule network of K562 cells. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Full text @ J Enzyme Inhib Med Chem