Image
|
Figure Caption
Figure 4. Compound 29e bind to the colchicine site of tubulin and inhibit the microtubule polymerisation. (A) 2 D model of the interaction between compound 29e and the amino acid residues of tubulin colchicine site. (B) 3 D model of the binding position of compound 29e. (C) RMSD tendency of two systems (29e, colchicine) versus time in the 60 ns MD simulation. (D) Effect of compound 29e on tubulin binding of [3H] colchicine. (E) Compound 29e affected microtubule assembly in vitro. (F) The effects of 29e on the organisation of cellular microtubule network of K562 cells.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ J Enzyme Inhib Med Chem