FIGURE

Fig. 7.

ID

ZDB-FIG-220205-51

Publication

Dal et al., 2021 - The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds

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Fig. 7.

In vivo efficacy of PM-formulated nNF derivatives against Mm infection in zebrafish embryos assessed by survival analysis. Mm-dsRed-infected zebrafish embryos were treated 1 day post infection with the indicated doses of the PM-formulated nNF derivates C7 (A), C11 (B), C12 (C) (5-50 mg/kg) or PM-formulated RIF (D) (5-20 mg/kg) by intravenous injection, and survival was recorded daily. Uninfected untreated embryos were used as a negative control (ctrl) and Mm-infected untreated embryos as an infection control group. Embryos used in this assay are the same as in the FPC assay (Fig. 6). Results are pooled from at least three independent experiments. na, not applicable. **P<0.01, ***P<0.001 (log-rank test of the Kaplan?Meier estimate of survival).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	bacterial treatment by injection: Mycobacterium marinum
Observed In:	whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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