FIGURE

Fig. 3

ID

ZDB-FIG-220131-417

Publication

Wang et al., 2021 - MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner

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Fig. 3

High MRE11 expression in oral cancer cells leads to chemoresistance, radioresistance, and decreased patient survival.

A The effect of MRE11 knockdown and overexpression on colony formation in oral cancer cells after ionizing radiation exposure. B The effect of MRE11 knockdown and overexpression on comet tail formation, an indicator for DSBs, in oral cancer cells after ionizing radiation treatment. C The effect of MRE11 knockdown and overexpression on γH2AX expression, an indicator for DSBs, in oral cancer cells after ionizing radiation exposure. D The effect of MRE11 knockdown and overexpression on oral cancer cell apoptosis, determined by TUNEL positivity, after ionizing radiation treatment. E The effect of MRE11 knockdown and overexpression on oral cancer cell apoptosis, determined by Annexin V positivity, after ionizing radiation treatment. F The effect of MRE11 expression, determined by IHC, on overall survival of oral cancer patients after radiotherapy.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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