FIGURE

Fig. 2

ID

ZDB-FIG-220131-412

Publication

Wang et al., 2021 - MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner

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Fig. 2

Metastasis-promoting activity of MRE11 in oral cancer cells is independent of its nuclease activity.

A MRE11 knockdown decreased, while its overexpression increased, wound closure in oral cancer cells. B MRE11 knockdown decreased, while its overexpression increased, transwell migration in oral cancer cells. C MRE11 knockdown decreased, while its overexpression increased, transwell invasion in oral cancer cells. D MRE11 knockdown decreased, while its overexpression increased, epithelial-to-mesenchymal transition in oral cancer cells. E Mirin, a MRE11 nuclease inhibitor, increased the expression of γH2AX, an indicator of DSB, in oral cancer cells upon ionizing radiation exposure. F Mirin treatment did not inhibit the proliferation-promoting activity of MRE11 in oral cancer cells. G Mirin treatment did not inhibit the migration-promoting activity of MRE11 in oral cancer cells. H Nuclease-deficient MRE11 with H129N mutation showed proliferation-promoting activity. I Nuclease-deficient MRE11 with H129N mutation showed migration-promoting activity.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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