FIGURE

Fig. 4

ID

ZDB-FIG-220131-145

Publication

Fabian et al., 2022 - Lifelong single-cell profiling of cranial neural crest diversification in zebrafish

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Fig. 4

a UMAP of 14 dpf SnapATAC data shows cell clusters for which top accessible peak modules were calculated for Constellations analysis. b Constellations analysis involves mapping of cluster-specific chromatin accessibility from 14 dpf back to earlier stages and then plotting relatedness of mapped accessibility in two dimensions. Diffuse refers to a stage when cluster-specific chromatin accessibility does not map to a discrete portion of UMAP space, and skewed when it does (see “Methods” for details). Groups of related cell types are color-coded. c Graphical representation from the Constellations analysis of when chromatin accessibility of major cell types first shows a skewed distribution in UMAP space, suggestive of establishment of competency.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	el10Tg/el10Tg; sd27Tg/sd27Tg
Observed In:	cranial neural crest chromatin remodeling neural crest cell differentiation pharyngeal arch cartilage chromatin remodeling
Stage Range:	Prim-25 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.