FIGURE

Fig 4

ID

ZDB-FIG-220131-104

Publication

Sveinsdóttir et al., 2022 - Motility phenotype in a zebrafish vmat2 mutant

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Fig 4

Radar chart for sleep parameters of dopamine agonist or precursor treated vmat2 larvae at night and day.

Homozygous vmat2 (HOM) larvae were either left untreated (naïve, grey colour) or treated with three different concentrations (1μM, light green colour; 10μM, green colour; and 100μM, dark green colour) of pramipexole or L-Dopa and sleep parameters were analysed. Pramipexole did not significantly alter any sleep parameters while L-Dopa significantly altered the sleep dynamics at multiple parameters in dose dependent manner during the night (A-B) whereas during the day both compounds had immense dose-depended effects on all parameters (C-D). Data are represented as fold change of untreated wild type (naïve, black colour) larvae. For values and statistics see Table 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc18a2^ui105/ui105
Conditions:	chemical treatment by environment: L-dopa chemical treatment by environment: pramipexole
Observed In:	sleep
Stage:	Day 6

Phenotype Detail

Acknowledgments

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