FIGURE

Fig. 2

ID

ZDB-FIG-220112-11

Publication

Mullapudi et al., 2019 - Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

dnVegfaa exerts a dose-dependent effect on ?-cell dispersion. (A) ?-Cells (green) from 48?hpf Tg(ins:GFP) embryos with mosaic Tg(ins:dnvegfaa) expression. The percentage of ?-cells expressing dnvegfaa (magenta) is indicated, as is the severity of islet dispersion (intact, moderate or severe; white). (B) Quantification of embryos displaying varying severity of islet dispersion. (C-J) Immunostaining for insulin (?-cells, red) and endothelial cells (green) in 48?hpf Tg(fli:GFP) embryos, in combination with the indicated transgenic or mutant line, n=3-5 animals per genotype. Maximum intensity projections are presented. A, anterior; D, dorsal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bns282Tg; zf5Tg bns284Tg; y1Tg bns286Tg; y1Tg flt1^bns29/bns29; y1Tg kdr^bns32/bns32; y1Tg kdrl^{hu5088/hu5088}; y1Tg vegfaa^bns1/bns1; y1Tg vegfab^bns92/bns92; y1Tg
Observed In:	blood vasculature endocrine pancreas endocrine pancreas blood vasculature primary islet
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development