FIGURE

Fig. 5.

ID

ZDB-FIG-220104-57

Publication

Habjan et al., 2021 - Anti-tuberculosis Compound Screen using a Zebrafish Infection Model identifies an Aspartyl-tRNA Synthetase Inhibitor

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Fig. 5.

TBA161-C has potent activity in the zebrafish infection model compared to other AspS inhibitors. (A) The chemical structures of the test compounds, TBA161-C, C1 and GSK93A. (B) Zebrafish embryos were yolk infected with M. marinum-tdTomato and treated with compounds at the indicated concentrations. Each data point represents the integrated red fluorescence intensity of a single zebrafish embryo, and the signal of each group is expressed as mean�s.e.m. Statistical significance was determined by one-way ANOVA, following Dunnett's multiple comparison test by comparing the signal from the DMSO-treated control sample with each treatment group (***P?0.001, ****P?0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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