FIGURE

Fig. 2.

ID

ZDB-FIG-220104-54

Publication

Habjan et al., 2021 - Anti-tuberculosis Compound Screen using a Zebrafish Infection Model identifies an Aspartyl-tRNA Synthetase Inhibitor

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Fig. 2.

Screening a library of anti-mycobacterial compounds in zebrafish-infection model identifies 14 hit-compounds. (A) Schematic representation of the screen design. Compounds active against Mtb and M. marinum in vitro were tested in the zebrafish embryo-M. marinum yolk-infection model. (B) Hit compounds were tested in a dose-response assay. Each data point represents the integrated red fluorescence intensity of a single zebrafish embryo, and the signal of each group (10-20 embryos) is expressed as mean�s.e.m. Statistical significance was determined by one-way ANOVA, following Dunnett's multiple comparison test by comparing the signal from the DMSO-treated control sample with each treatment group (*P?0.05, **P?0.01, ***P?0.001, ****P?0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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