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FIGURE 4

ID

ZDB-FIG-220104-18

Publication

Hwang et al., 2021 - Enhanced anti-angiogenic activity of novel melatonin-like agents

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FIGURE 4

NB-5-MT (2) suppresses hypoxia-mediated angiogenesis in vitro. (A-B) Under hypoxia, HCT116 cells were incubated with 1 mM of melatonin (M) or 2 for 16 hr Conditioned medium (CM) was collected from HCT116 cells or MDA-MB-231 cells and added to HUVECs for angiogenesis assays. (A) Inhibitory effect of 2 on angiogenesis in human umbilical vein endothelial cells (HUVECs) in vitro. Representative images of tube formation (top), invasion (middle), and migration (bottom) assays from 3 independent experiments. (B) Relative anti-angiogenic effect of 2 using the conditioned media of HCT116 cells. Graphs of in vitro tube formation (left), invasion (middle), and migration (right). (C) Relative anti-angiogenic effect of 2 using the conditioned media of MDA-MB-231 cells. Graphs of in vitro tube formation (left), invasion (middle), and migration (right). Data are the mean ± SD from 3 independent experiments. *P <.05 and **P <.01, vehicle vs. hypoxia; +P <.05 and ++P <.01, hypoxia vs. hypoxia plus compound treatment

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Pineal Res.