FIGURE

Figure 7

ID

ZDB-FIG-220104-165

Publication

Taranta et al., 2021 - Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis

Other Figures

All Figure Page

Back to All Figure Page

Figure 7

A hypothetical model illustrating the effects of DSF in cystinotic cells. DSF (DDC-S-S-DDC) is a disulfide that is reduced to diethyldithiocarbamate (DDC) in the cytosol, consuming GSH and other free thiols. Consequently, cells are more exposed to free radicals, causing oxidative cell damage and death. Similarly to cysteamine, reduced DDC can react with cystine (C-SS-C) in lysosomes, forming a mixed disulfide (DDC-S-S-C) that allows clearance of cystine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cells