FIGURE

Figure 2

ID

ZDB-FIG-220104-101

Publication

Gharbi et al., 2021 - Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina

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Figure 2

Laminar morphology of wild-type, knockout and transgenic retinas. Light microscopic images of toluidine-blue-stained retinal cross-sections from nine-month-old adult zebrafish: (A) wild type, (B) DJ-1 knockout, (C) Müller-cell-expressed wild-type DJ-1, (D) Müller-cell-expressed DJ-1c106a mutant. (E). Retinal thickness (μm) measured on eye sections from three fish in each group. **** p < 0.0001, one-way ANOVA, n = 17 (WT), 10 (KO_DJ-1), 15 (Müller_DJ-1) and 19 (Müller_DJ-1c106a). (F) Number of cells in ganglion cell layer measured on sections from three fish; ** p < 0.01, *** p < 0.001 and **** p < 0.0001 versus wild type, one-way ANOVA, n = 6). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer nuclear layer; PR, photoreceptors; RPE, retinal pigment epithelium; V, vacuole in RPE layer. Bar, 20 μm applies to all panels.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	park7^{ub2000/ub2000} park7^{ub2000/ub2000}; ub1001Tg park7^{ub2000/ub2000}; ub2003Tg
Observed In:	retina retinal ganglion cell retinal photoreceptor layer retinal pigmented epithelium vacuole
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)