FIGURE

Fig. 1

ID

ZDB-FIG-211230-98

Publication

Arias-Alpizar et al., 2021 - Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles

Other Figures

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Fig. 1

Generation and characterization of stab1 and stab1/stab2 mutants. (A) Schematic representation of a stab1 domain structure predicted to be expressed from the wt Stabilin-1 and the stab1ibl3 allele. (B) In situ hybridization (ISH), mRNA expression of stab1, stab2, and mrc1 in wt, stab1ibl3, stab2ibl2 single mutants and stab1ibl3stab2ibl2 double mutant. *Reduced expression. (C) Tg(fli1:RFP fli4:YFP) stab1ibl3 single mutant, stab1ibl3stab2ibl2 double mutant, and sibling at 5 dpf. Scale bar: 250 μm. (d) Representative fertile adult female stab1ibl3 single mutant, stab1ibl3stab2ibl2 double mutant and sibling zebrafish.

Expression Data

Genes:	mrc1a stab1 stab2
Fish:	WT
Anatomical Term:	caudal hematopoietic tissue
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stab1^ibl3/ibl3 stab2^ibl2/ibl2 stab1^ibl3/ibl3; hu5333Tg; hu7135Tg stab1^ibl3/ibl3; stab2^ibl2/ibl2 stab1^ibl3/ibl3; stab2^ibl2/ibl2; hu5333Tg; hu7135Tg
Observed In:	blood vasculature kidney lymph vasculature whole organism
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Nanomedicine : nanotechnology, biology, and medicine, 34, Arias-Alpizar, G., Koch, B., Hamelmann, N.M., Neustrup, M.A., Paulusse, J.M.J., Jiskoot, W., Kros, A., Bussmann, J., Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles, 102395, Copyright (2021) with permission from Elsevier. Full text @ Nanomedicine