FIGURE

Fig. 4

ID

ZDB-FIG-211230-101

Publication

Arias-Alpizar et al., 2021 - Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles

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Fig. 4

LPS clearance is mediated by Stabilin-1 and Stabilin-2. (A) Biodistribution of Alexa488 LPS (1 nL of 500 μm/mL) in wt (AB/TL), (B) stab2ibl2 mutant, (C) stab1ibl3 mutant, (D) stab1ibl3stab2ibl2 double mutant at 56 hpf, 1.5 hpi, whole body view (10×). Scale bar: 200 μm. (E-H) Tissue level views, caudal region (40×). Scale bar: 50 μm (I) Graph represents intensity of fluorescent LPS in wt and stab mutants. Bar height represents median values, dots represent individual data points, and brackets indicate significant values (*P ˂ 0.05, ***P ˂ 0.001) based on Kruskal–Wallis tests followed by two-tailed Dunn’s tests with Bonferroni correction. The images shown in E-H correspond to the fish used in A-D and are one of the images used for the graph in I.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Nanomedicine : nanotechnology, biology, and medicine, 34, Arias-Alpizar, G., Koch, B., Hamelmann, N.M., Neustrup, M.A., Paulusse, J.M.J., Jiskoot, W., Kros, A., Bussmann, J., Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles, 102395, Copyright (2021) with permission from Elsevier. Full text @ Nanomedicine