Fig. 1

Effects of treatments with CPBMF-223 (50 mg/kg/day, 5 days/week, 3 weeks) and 5-fluorouracil (5-FU; 30 mg/kg/day, every other day), by intraperitoneal (i.p.) route, on tumor relative volume (RTV) and body weight changes (%) in nude mice injected with human colorectal carcinoma (HCT-116). RTV curve during treatment for female (A) and male (B) mice. Body weight changes curve for female (C) and male (D) animals. Representative pictures to show the sizes of the tumors excised on day 21 (E). Chemical structure of 6-(((1,3-dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione (CPBMF-223) (F). 5-FU treatment was used as a positive control drug for colorectal cancer. Data were expressed with the mean ± standard error of the mean. Statistical analysis was performed by two-way analysis of variance, followed by Bonferroni post-test. Data significant in relation to vehicle (negative control group) at *p < 0.05, **p < 0.01, and ***p < 0.001. q.o.d.: every other day.