FIGURE

Figure 4

ID

ZDB-FIG-211201-142

Publication

Dard et al., 2021 - DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Mechanisms of impaired fertility in Tg mice overexpressing DYRK1A. Hypogonadotropic hypogonadism (a) might be induced by central overexpression of DYRK1A in the hypothalamus and/or the pituitary; the overexpression might be responsible for lowering the production of LH and FSH gonadotrophins. In the testis, low LH levels slow down steroidogenesis and reduce testosterone levels, which in turn reduced spermatogenesis stimulation and upregulation of AMH levels in Sertoli cells. In germ cells (b), overexpression of DYRK1A in the early stages of spermatogenesis prompts spermatogonia to self-renew rather than to differentiate and enter meiosis. This process might be mediated by activation of STAT3 and GDNF, downregulation of retinoic acid (RA), and perturbation of the mitosis-to-meiosis transition by excess AMH.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genes (Basel)