PUBLICATION
DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis
- Authors
- Dard, R., Moreau, M., Parizot, E., Ghieh, F., Brehier, L., Kassis, N., Serazin, V., Lamaziere, A., Racine, C., di Clemente, N., Vialard, F., Janel, N.
- ID
- ZDB-PUB-211129-53
- Date
- 2021
- Source
- Genes 12(11): (Journal)
- Registered Authors
- Keywords
- DYRK1A, Down syndrome, infertility
- MeSH Terms
-
- Animals
- Hypogonadism/genetics*
- Hypogonadism/pathology
- Infertility, Male/genetics*
- Infertility, Male/pathology
- Male
- Mice
- Mice, Inbred C57BL
- Protein Serine-Threonine Kinases/genetics*
- Protein Serine-Threonine Kinases/metabolism
- Protein-Tyrosine Kinases/genetics*
- Protein-Tyrosine Kinases/metabolism
- Spermatogenesis*
- Testis/embryology
- Testis/pathology
- Up-Regulation
- PubMed
- 34828406 Full text @ Genes (Basel)
Citation
Dard, R., Moreau, M., Parizot, E., Ghieh, F., Brehier, L., Kassis, N., Serazin, V., Lamaziere, A., Racine, C., di Clemente, N., Vialard, F., Janel, N. (2021) DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis. Genes. 12(11):.
Abstract
Down syndrome (DS) is the most common chromosomal disorder. It is responsible for intellectual disability (ID) and several medical conditions. Although men with DS are thought to be infertile, some spontaneous paternities have been reported. The few studies of the mechanism of infertility in men with DS are now dated. Recent research in zebrafish has indicated that overexpression of DYRK1A (the protein primarily responsible for ID in DS) impairs gonadogenesis at the embryonic stage. To better ascertain DYRK1A's role in infertility in DS, we investigated the effect of DYRK1A overexpression in a transgenic mouse model. We found that overexpression of DYRK1A impairs fertility in transgenic male mice. Interestingly, the mechanism in mice differs slightly from that observed in zebrafish but, with disruption of the early stages of spermatogenesis, is similar to that seen in humans. Unexpectedly, we observed hypogonadotropic hypogonadism in the transgenic mice.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping