FIGURE

Fig 9

ID

ZDB-FIG-211122-31

Publication

Kikel-Coury et al., 2021 - Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

Other Figures

All Figure Page

Back to All Figure Page

Fig 9

CNG control heart function through sympathetic/parasympathetic modulation.

(A) Schematic of sympathetic and parasympathetic regulation of cardiac function through communication with the ICNS. (B) Quantification of the number of ventricular contractions with sympathetic agonist (isoproterenol) treatment over various location ablation of nucGFP⁺ cells. (C) Quantification of the number of ventricular contractions with parasympathetic agonist (carbachol) treatment over various location ablation of nucGFP⁺ cells. (D) Quantification of percent duration of ventricular fibrillation in metrn^−/− animals after treatment with the isoproterenol or carbachol. (E) Schematic of overall findings of CNG showing that they originate from the neural crest and require metrn to generate gfap⁺ cells that control heart rate and rhythm. Data are represented as mean ± SEM. Statistics summarized in S1 Table. See S1 Data for raw data. A, atrium; ANS, autonomic nervous system; bpm, beats per minute; CNG, cardiac nexus glia; ICNS, intracardiac nervous system; OT, outflow tract; V, ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT metrn^nt200/nt200; mi2004Tg
Conditions:	chemical treatment by environment: carbachol chemical treatment by environment: L-isoprenaline
Observed In:	heart contraction
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.