FIGURE

Figure 4

ID

ZDB-FIG-211029-275

Publication

Chiang et al., 2021 - Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Cell cycle progression and cell proliferation were suppressed in GrnA morphants after PHx. (A) Cell cycle analysis of hepatectomized control and GrnA morphant zebrafish for 0 h (upper) and 24 h (lower) after PHx. PI staining was performed, and samples were analyzed using flow cytometry. The proportion of cells at each stage at 0 h (B) and 24 h (C) after PHx was analyzed by Flow-Jo software and is presented as mean ± SD. The cell cycle regulatory genes included (D) ccnd1, (E) ccne, and (F) ccna2, and (G) myc, the cell proliferation related gene, was probed by quantitative PCR. Data are shown as relative expression of indicated genes normalized to control 0 h after PHx. EF1a served as the internal control. Significance was set at * p < 0.05, ** p < 0.01, *** p < 0.001, as determined by t-test; PHx, partial hepatectomy.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.