FIGURE

Fig. 5

ID

ZDB-FIG-211012-5

Publication

Rattka et al., 2021 - Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish

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Fig. 5

(A,B) Lateral view of Cx43-deficient (B) and control-injected embryos (A) at 72 hpf. Cx43 deficiency results in development of a large pericardial edema at 72 hpf (B, black arrow) while the controls don't display cardiac abnormalities (A). (C) 47% (47/99) MO-cx43_ATG- injected embryos displayed a heart failure and arrhythmia phenotype. Embryos with pericardial edema, bradycardia, and impaired contractility were counted as affected. (D) Efficacy of morpholino-mediated knockdown experiments was confirmed by Western Blot analysis. Images (A, B) have been cropped. C: Assessment of significance by chi-squared test. ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU + MO6-gja1b
Knockdown Reagent:	MO6-gja1b
Observed In:	heart contraction pericardium
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Journal of Molecular and Cellular Cardiology, 155, Rattka, M., Westphal, S., Gahr, B.M., Just, S., Rottbauer, W., Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish, 25-35, Copyright (2021) with permission from Elsevier. Full text @ J. Mol. Cell. Cardiol.