FIGURE
Figure 1
- ID
- ZDB-FIG-210707-37
- Publication
- Ma et al., 2021 - Inhibiting Endothelial Cell Function in Normal and Tumor Angiogenesis Using BMP Type I Receptor Macrocyclic Kinase Inhibitors
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Figure 1
Structure and kinase profile of OD16 and OD29. (A–C) Chemical structure and the activity of a panel of 96 kinases in the presence of 100 nM of OD16 (A), OD29 (B), and LDN-193189 (C). (D) Affinity (Kd) of OD16, OD29, and LDN-193189 for the BMP, activin, and TGF-β type I and type II kinase receptors. (E,F) Structural model of OD16 (E) and OD29 (F) binding to the ALK1 hinge region in the ATP pocket. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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