Image
|
Figure Caption
Figure 1 Structure and kinase profile of OD16 and OD29. (A–C) Chemical structure and the activity of a panel of 96 kinases in the presence of 100 nM of OD16 (A), OD29 (B), and LDN-193189 (C). (D) Affinity (Kd) of OD16, OD29, and LDN-193189 for the BMP, activin, and TGF-β type I and type II kinase receptors. (E,F) Structural model of OD16 (E) and OD29 (F) binding to the ALK1 hinge region in the ATP pocket.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Cancers