FIGURE

Fig. S1

ID

ZDB-FIG-210521-1

Publication

Asakawa et al., 2020 - Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons

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Fig. S1

The structure of human and zebrafish Tardbp/TDP-43 proteins. RRM, RNA-recognition motif. IDR, intrinsically disordered region. (b, c) The tardbp-n115 and tardbpl-n94 mutations are frame-shift deletions that cause protein truncation. The deleted nucleotides were indicated by red lower cases. The grey bars indicate ectopically added peptide due to the frame shift. (d) The lateral views of the wild type (top) and double homozygous (bottom) larvae at 48 hpf. The arrow and arrowhead indicate the swollen heart and the stacked red blood cells on the far side of the yolk, respectively. The bar indicates 250 μm. (e) Rescue rate of the blood circulation defect of the tardbp-n115 tardbpl-n94 homozygotes (DKOs). The numbers on the histograms show the total numbers of DKOs investigated (Source data are provided as a Source Data file). Error bars show SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tardbpa^nkz4/nkz4; tardbpb^nkz3/nkz3
Observed In:	blood circulation common cardinal vein nucleate erythrocyte pericardium whole organism
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.