FIGURE

Fig. 4

ID

ZDB-FIG-210519-90

Publication

Tseng et al., 2021 - The role of Niemann-Pick type C2 in zebrafish embryonic development

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Fig. 4

(A) npc2m/m larvae are mostly identical to npc2^+/+ at 6 dpf; however, a few npc2m/m larvae lacked inflated swim bladders or had dorsally curved body axis. A total of 105 npc2^+/+ and 112 npc2m/m from five crosses were examined. Numbers of larvae showing representing phenotypes are indicated in each image. Scale bar: 1 mm. (B) Live images of 10 wpf npc2m/m adults showed relatively normal morphology but smaller body size compared with npc2^+/+ individuals. Occasionally, npc2^m/m adults exhibited scoliosis. Scale bar: 5 mm. (C) Total length of npc2^+/+ (31.16±3.01 mm), npc2^+/m (31.34±2.68 mm) and npc2^m/m (26.62±4.76 mm) adults at 10 wpf. A total of 16 npc2^+/+, 32 npc2^+/m and 26 npc2^m/m adults were examined from two independent crosses. ***P<0.001 (one-way ANOVA and Tukey's test). Total length is presented as mean±s.d. NS, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npc2.1^y536/y536 (EKW)
Observed In:	post-vent region swim bladder vertebral column whole organism
Stage Range:	Day 6 to Days 45-89

Phenotype Detail

Acknowledgments

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