FIGURE

Figure 6

ID

ZDB-FIG-210503-81

Publication

Geng et al., 2021 - Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration

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Figure 6

Inhibition of blood flow and Notch signaling attenuates lepb induction during ventricle regeneration. (A–G) Whole-mount in situ hybridizations showed that lepb expression in ablated hearts of Tg(vmhc:mCherry-NTR) fish at 24 hpt (A) was reduced in the Tricaine- and BDM-treated groups (B,C) and in the DAPT-treated group (D), slightly enhanced in the Car-treated group (E), and remained unchanged in the K02288- and LDN-treated groups (F,G). Scale bars, 25 μm. Dashed lines outline the hearts. Numbers indicate the ratio of representative staining observed. hpt, hours post treatment; Car, Cardiomogen-1; LDN, LDN193189.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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