FIGURE

Fig 6

ID

ZDB-FIG-210503-149

Publication

Wright et al., 2021 - Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis

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Fig 6

Cxcl12a knockdown places the Cxcl12/Cxcr4 signalling axis downstream of miR-206.

(A) Whole body neutrophil counts at 3 dpi of cxcl12a and double (cxcl12a and miR-206) knockdown embryos. (B) Measurement of neutrophil recruitment to M. marinum following trunk injection in double knockdown embryos. (C) Bacterial burden at 3 dpi in M. marinum-infected double knockdown embryos. Each data point represents a single measurement, with the mean and SEM shown. For time-lapse imaging, each data point represents the mean of 4 foci of infection from 4 separate embryos. Bacterial burden analysis was performed on 20–30 embryos per treatment. Graphs are representative of 2 biological replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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